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Sophia Inbaraj

Sophia Inbaraj

ICAR-Central Island Agricultural Research Institute, Andaman and Nicobar Islands, India

Title: Quantitative expression of hepatic Toll-Like Receptor 1–10 mRNA in Osmanabadi goats during different climatic stresses


Biography: Sophia Inbaraj


A study was conducted to establish the impact of heat stress, nutritional stress and combined stresses (heat and nutritional) on TLR genes expression in liver samples of Osmanabadi goats. Twenty four adult Osmanabadi male goats (average body weight 16.0 kg) were divided into four groups viz., C (n=6; control), HS (n=6; heat stress), NS (n=6; nutritional stress) and CS (n=6; combined stress). The study was conducted for a period of 45 days. C and HS goats had ad libitum access to their feed while NS and CS goats were under restricted feed (30% intake of C bucks) to induce nutritional stress. The HS and CS goats were exposed to solar radiation for six hours a day between 10:00 h to 16:00 h to induce heat stress. The animals were slaughtered at the end of study and their liver samples were collected for different TLR gene expression. Except TLR5 and TLR9, higher expression of all other TLR receptors in liver was observed in HS group. Animals exposed to CS expressed high amount of TLR5 in liver. Although higher expression of TLR9 was obtained in all stress groups (HS, NS and CS), than control group, still the expression did not varied between the stress groups. The higher expression of majority of the TLR gene in HS groups indicates that when nutrition is not compromised heat stressed animals were able to sustain their immune functions. This is the first report on impact of different climatic stress on TLR gene expression in large animals and these results could serve as reliable baseline information for future research efforts pertaining to impact of climate change on immune response in livestock species.