Cletus A Ukwubile
Federal Polytechnic Bali, Nigeria
Title: Anti-microbial properties and characterization of annona muricata linn loaded chitosan nanoparticles against cancer associated microbes
Biography
Biography: Cletus A Ukwubile
Abstract
Annona muricata chitosan nanoparticles (AMCS), nano-seized drug carriers were prepared by ionic gelation of chitosan and sodium tripolyphosphate (TPP) anions. Antimicrobial properties and characterization of A. muricata chitosan formulation of leaf methanol extract were evaluated on ten cancer associated microbes; Bacillus subtilis NCTC8239, Salmonella typhi ATCC9184, Staphylococcus aureus NCTC6571, E.coli NCTC10418, Staphylococcus aureus (clinical isolate), MRSA (clinical isolate), Streptococcus pyogenes (clinical isolate), Klebsiella pneumonia ATCC 10031, Candida albican ATCC 19231 and Staphylococcus aureus NCTC 6571 using agar well diffusion method. AMCS exhibited great antimicrobial properties against all the microbes which were significantly different from that of the broad spectrum antibiotic ceftriaxone 10 mg; USP. Compatibility of A. muricata loaded chitosan nanoparticles as revealed by atomic force and transmission electron microscopes showed that chitosan nanoparticles are effective drug carriers for both antimicrobial and anticancer agents. The study showed that chitosan loaded plant extract of Annona muricata is a sure promise towards treating some infectious diseases such as cancer and microbial infections.