Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 9th Biotechnology Congress Orlando,Florida, USA.

Day 1 :

Keynote Forum

Kiminobu Sugaya

University of Central Florida, USA

Keynote: Stem cell based therapies for neurodegenerative diseases under the pathological condition

Time : 9:00-09.50AM

Conference Series Biotechnology Congress-2015 International Conference Keynote Speaker Kiminobu Sugaya photo
Biography:

Kiminobu Sugaya is a Professor of Medicine in Burnett School of Biomedical Science, College of Medicine, University of Central Florida (UCF) since 2004. He is a Director of Multidisciplinary Neuroscience Alliance of UCF, a Chair of Neuroscience Consortium for Central Florida and a Chair of Central Florida Chapter of Society for Neuroscience. He earned BSM and PhD from the Science University of Tokyo. He received a Post-doctoral training from Dr. Ezio Giacobini, who built the base for the current cholinesterase Alzheimer’s disease therapies, at the Southern University of Illinois. He moved to the Department of Psychiatry in the School of Medicine at the University of Illinois at Chicago in 1997 where he became Associate Professor. He has further expanded his research area to the use of stem cell. His publication regarding improvement of memory in the aged animal by stem cell transplantation was reported Washington Post, BBC, NBC, ABC and other media in all over the world.

Abstract:

Advances in stem cell technologies; including the ability to produce pluripotent stem cells from adult stem cells by the over expression of an embryonic stem cell gene and to increase endogenous stem cells by administration of a small molecule may bring a cure for neurodegenerative diseases. However in order for the stem cells to be functional, they have to be differentiated into the proper types of cells and integrated into the proper part of the host brain. Thus we need to consider the pathological condition of the disease, which may. Thus, we have to consider the pathological environment that might alter environmental cues for migrate and differentiate of the stem cells. Here we show the effects of amyloid precursor protein (APP) and reelin on neural stem cell (NSC) differentiation and how to regulate this effect to produce desirable cells under pathological conditions. We found that APP increases glial differentiation via the notch and cytokine-signaling pathway, while reelin induces radial glial differentiation followed by neuronal differentiation via increasing phosphorylation of adapter protein disable-1. Since amyloid and reelin are found in the plaques within Alzheimer's disease (AD), these findings may closely associate with NSC biology under its pathology. By regulating these factors in AD, we may be able to not only guide differentiation of transplanted NSCs but also modify progression of disease by guiding differentiation of endogenous NSCs.

Conference Series Biotechnology Congress-2015 International Conference Keynote Speaker Charles H Williams photo
Biography:

Charles H Williams completed his PhD in 1968 and then a Post-Doctoral at the Institute for Enzyme Research with David E Green on mitochondrial studies. He also published with Henry A Lardy at the Enzyme Institute. He moved to Missouri as Associate Professor of Biochemistry and Assistant Professor of Medicine. He relocated to TTUHSC-El Paso in 1982 where MH research was his primary area of interest. He has published over 50 papers in refereed journals and has presented posters and lectures at many international events.

Abstract:

Introduction: The malignant hyperthermia gene is inherited as a dominant gene. There are variable degrees of penetrance so a colony of MHS pigs must be established to provide susceptible animals for experimental studies. We have used our MHS pig colony for over 20 years. The MHS pig colony was started in January 1969 at Wisconsin; it was moved to Missouri in 1973 and on to El Paso, TX in 1982. Methods: We completed an experimental study of Sevoflurane in 1984 with MHS pigs. We found Sevoflurane to be an exceptionally smooth anesthetic with no side effects. Sevoflurane usage in clinical practice has reduced the incidence of MH by eleven fold since it was approved for human use. It is an outstandingly good anesthetic with minimal side Results: Non-depolarizing muscle relaxants such as Pancuronium, Vecuronium, Metubine iodide and Orgnon 9416 (Rocuronium) do not trigger an MH episode in experimental MHS pigs. Similar results are observed in human patients. Succinyl choline is a potent trigger of MH in pigs and human patients. Organon 9426 offers protective effects after 100% muscle twitch response has been recovered in MHS pigs. MHS pigs have a 30-35% decrease in acetylcholine receptors at the myoneural junction. These observations suggest either a decrease in the synthesis of acetylcholine receptor proteins or an increased degradation of dysfunctional acetylcholine receptors. Conclusion: The Ryanodine receptor appears to be involved in MH as a secondary or tertiary participant in triggering the MH syndrome.

Conference Series Biotechnology Congress-2015 International Conference Keynote Speaker Charles H Williams photo
Biography:

Charles H Williams completed his PhD in 1968 and then a Post-Doctoral at the Institute for Enzyme Research with David E Green on mitochondrial studies. He also published with Henry A Lardy at the Enzyme Institute. He moved to Missouri as Associate Professor of Biochemistry and Assistant Professor of Medicine. He relocated to TTUHSC-El Paso in 1982 where MH research was his primary area of interest. He has published over 50 papers in refereed journals and has presented posters and lectures at many international events.

Abstract:

The malignant hyperthermia gene is inherited as a dominant gene. There are variable degrees of penetrance so a colony of MHS pigs must be established to provide susceptible animals for experimental studies. We have used our MHS pig colony for over 20 years. The MHS pig colony was started in January 1969 at Wisconsin; it was moved to Missouri in 1973 and on to El Paso, TX in 1982. We completed an experimental study of Sevoflurane in 1984 with MHS pigs. We found Sevoflurane to be an exceptionally smooth anesthetic with no side effects. Sevoflurane usage in clinical practice has reduced the incidence of MH by eleven fold since it was approved for human use. It is an outstandingly good anesthetic with minimal side effects. Non-depolarizing muscle relaxants such as Pancuronium, Vecuronium, Metubine iodide and Orgnon 9416 (Rocuronium) do not trigger an MH episode in experimental MHS pigs. Similar results are observed in human patients. Succinyl choline is a potent trigger of MH in pigs and human patients. Organon 9426 offers protective effects after 100% muscle twitch response has been recovered in MHS pigs. MHS pigs have a 30-35% decrease in acetylcholine receptors at the myoneural junction. These observations suggest either a decrease in the synthesis of acetylcholine receptor proteins or an increased degradation of dysfunctional acetylcholine receptors.The Ryanodine receptor appears to be involved in MH as a secondary or tertiary participant in triggering the MH syndrome.

Keynote Forum

Ayoub A Bazzaz

University of King Abdulaziz, KSA

Keynote: The curing potency of the natural honey against the toxicity of Doxorubicin in kidneys of mice

Time : 11.20 - 12. 05

Conference Series Biotechnology Congress-2015 International Conference Keynote Speaker Ayoub A Bazzaz photo
Biography:

Ayoub A Bazzaz has completed his PhD from Nottingham University, UK and continued Post-doctoral research works at Leeds, Liverpool in UK and Cardiff Universities in South Wales. He was the Head of Anatomy Department at Medical School of Tikrit University, Iraq. Since then he has been working as an academic and researcher and has supervised and refereed many PhD and MSc students in Iraq, KSA, Libya and UK. He has published over 50 scientific papers in reputed journals.

Abstract:

Using biochemical and histological measurements the current study involved the assessment of curing potency of the natural honey against the toxic effects of Doxorubicin on kidney of mice. A total of 106 healthy male Albino mice Mus musculus strain weighing 37±3 gm were used. Experimental mice were intra-peritoneal injected a dose of Doxorubicin (DOX) of 4 mg/Kg/week for seven weeks while the treated groups (DOX + honey) were fed on the pure natural honey, on daily basis. The toxic effects of DOX on renal tissue involved loss of weight, destruction of kidney structures, blood congestion, accumulation of inflammatory cells and atrophied glomeruli, detachment of the cellular lining of the renal tubules. In addition, cellular disintegration in renal tissues i.e. necrosis, fibrosis and vacuulation were comparable to those of control. Daily ingestion of natural honey for 7 weeks has led to significant (p≤0.01-0.001) improvement of these symptoms which represented as an increase in body weight in comparison with control animals while renal tissues showed general cellular integrity in normal renal capsules, glomeruli, Bowman\\\'s capsules and convoluted tubules. It is concluded that the ingestion of natural honey has a protective potency against the toxic effects of DOX in kidney tissues.

Keynote Forum

Suman Kapur

Birla Institute of Technology and Science, India

Keynote: Environment and health approaches for mitigating ill-health effects of environment degradation

Time : 12.05 - 12.50

Conference Series Biotechnology Congress-2015 International Conference Keynote Speaker Suman Kapur photo
Biography:

Suman Kapur completed her PhD from AIIMS New Delhi and Post-doctoral studies from University of Minnesota. She is the Dean, International Programmer and Collaboration Division at the premier All India Higher Education center, Birla Institute of Technology and Science Hyderabad campus, Hyderabad. She has been an Awardee of Lalor Foundation, USA, and published more than 175 papers in reputed journals and serving as an Editorial Board Member of several journals of international repute. She also serves on several national committees on nutraceuticals, food safety & security and disaster management.

Abstract:

Virtually all-human diseases result from the interaction of genetic susceptibility factors and modifiable environmental factors, broadly defined to include infectious, chemical, physical, nutritional & behavioral factors. Variations in genetic makeup are associated with almost all disease and this influence a person’s susceptibility to environmental factors. DNA methylation leaves indicators, or marks, on the genome and there is evidence that these marks are strongly influenced by external factors such as the environment and diet. Integrated approach to the study of chronic diseases is not the need of the hour, as neither nature nor nurture, alone can explain the molecular processes of human health or disease. There are thousands of chemicals in the modern environment and many of them are present in measurable levels in us. Diet is believed to be one of the main sources of exposure to potentially dangerous chemicals and with every meal we may be unwittingly exposed to chemicals used while growing, processing and packaging of food. Thus, dietary chemicals include nutrients and bioactive chemicals that do not directly produce energy and man-made chemicals such as pesticides. These chemicals, in turn, affect the body in many ways, from disrupting hormone action to modulating gene expression to impairing cognitive function to increasing the risk of obesity. Data from numerous molecular and genetic epidemiological studies indicate that gene–environment interactions, via dietary changes, can interact in ways that modulate the risk for developing chronic diseases. Therefore, dietary intervention based on knowledge of nutritional requirement, nutrition status, and genotype can be used to prevent, mitigate or cure chronic disease.

  • Biotechnology in Healthcare ; Cancer Biology; Food and Bioprocess Technology

Chair

Ayoub Bazzaz

University of King Abdulaziz, Kingdom of Saudi Arabia

Co-Chair

Xianyong Ma

Yale Medical School, USA

Session Introduction

Ayoub Bazzaz

University of King Abdulaziz, Kingdom of Saudi Arabia

Title: The curing potency of the natural honey against the toxicity of doxorubicin in kidneys of mice

Time : 11:20-11:50

Speaker
Biography:

Ayoub A Bazzaz has completed his PhD from Nottingham University, UK and continued Post-doctoral research works at Leeds, Liverpool in UK and Cardiff Universities in South Wales. He was the Head of Anatomy Department at Medical School of Tikrit University, Iraq. Since then he has been working as an academic and researcher and has supervised and refereed many PhD and MSc students in Iraq, KSA, Libya and UK. He has published over 50 scientific papers in reputed journals.

Abstract:

Using biochemical and histological measurements the current study involved the assessment of curing potency of the natural honey against the toxic effects of doxorubicin on kidney of mice. A total of 106 healthy male Albino mice Mus musculus strain weighing 37±3 gm were used. Experimental mice were intra-peritoneal injected a Dose of Doxorubicin (DOX) of 4 mg/Kg/week for seven weeks while the treated groups (DOX + honey) were fed on the pure natural honey, on daily basis. The toxic effects of DOX on renal tissue involved loss of weight, destruction of kidney structures, blood congestion, accumulation of inflammatory cells and atrophied glomeruli, detachment of the cellular lining of the renal tubules. In addition, cellular disintegration in renal tissues i.e. necrosis, fibrosis and vacuulation were comparable to those of control. Daily ingestion of natural honey for 7 weeks has led to significant (p≤0.01-0.001) improvement of these symptoms which represented as an increase in body weight in comparison with control animals while renal tissues showed general cellular integrity in normal renal capsules, glomeruli, Bowman's capsules and convoluted tubules. It is concluded that the ingestion of natural honey has a protective potency against the toxic effects of DOX in kidney tissues.

Speaker
Biography:

Xianyong Ma received his PhD degree with honors from Central South University in P. R. China, and finished his Post-doctoral studies from Yale University. At present, as a Research Scientist he is working on the mechanism of Human Endometrial Carcinogenesis at Molecular Level in Yale Medical School. He has published more than 40 papers in reputed journals, two book chapters regarding micro-array chips and molecular carcinogenesis, and has been serving as an Editorial Board Member of two reputed journals. He is a Founding Member of Epigeno-max Company for development of new treatment strategy of cancers and cardiologic diseases.

Abstract:

Human Endometrial Stromal Sarcoma (ESS) represents a very rare gynecological malignant tumor that originates from endometrial stromal cells. Tumorigenesis of ESS can originate from abnormal hormone estrogen level/bleeding, and possible from the chemical insult, radiation and viral infection, as well as genetic predispositions. Recently findings indicate that this type of tumor is highly associated with chromosomal translocation including t (6; 10) (p21; p11) (very rare), t (6; 7) (p21; p15) (25%) and t (7; 17) (p15; q21) (>50%). These translocations result in production of the fusion proteins of EPC-PHF1, JAZF1-PHF1 and JAZF1-SUZ12 respectively. Very interestingly both of PHF1 and SUZ12 are the poly-comb proteins that involve in poly-comb repressive complex 2/3 (PRC2/3), which is one of the most critical complexes for chromatin compaction and gene inactivation. In this study, we established the HESC cell lines that stably express fusion protein JAZF1-SUZ12, wild type JAZF1 and SUZ12 respectively, carried out the proliferation assay for these cells. The cell line with over expression of fusion protein has significant higher proliferation rate in comparison with the cell line over expressed SUZ12 (P=0.01<0.05), and shows the features of de-differentiation. Next, we globally detected the gene expression patterns for these cell lines together with ESS samples from Yale New-Haven hospital by using micro-array technique. We identified there were 12,817 genes (in total 47323 genes) with same expression behavior among HESC/JAZF1-SUZ12, ESS tumor 1# and ESS tumor 2#. 156 genes with known function are significantly up-regulated (>2 fold) and 15 genes are significantly down-regulated (>2 fold) only in these three samples. These data were further confirmed by qRT-PCR. Analysis of the 156 up-regulated gene indicates there are 9 signaling pathways which are activated and 8 are significant; both P and Benjamini values <0.05 including WNT and cancer signaling pathways. The WNT1, WNT3a, WNT7b, WNT11 and APC2, which are highly up regulated, are involved in both signaling pathway. CHIP analysis shows these four WNT genes are the down stream targets of PRC2-SUZ12, therefore we reasonably detected the tri-methylation level of histone 3 lysine 27 (H3K27Me3) by CHIP assay using anti-H3K27Me3 antibody. Our study shows the fusion protein is significantly decreased the H3K27Me3 level on the promoter region of these target genes (compare with wild type SUZ12). In summary, we confirmed fusion protein of JAZF1-SUZ12 causes the WNT signaling activation via decreasing the H3K27Me3 level on target promoter regions in ESS tumorigenesis. A numbers of small molecule inhibitors of WNT members and RNA interference technique are being used to confirm if inactivating the highly activated WNT signaling pathway can reverse the proliferation ability and stop de-differentiation process of HESC/JAZF1-SUZ12 cells and primary ESS tumor cells.

Gong YL

Nanjing Medical School, China Panel Discussion

Title: Therapeutic value of Chinese herbal decoction in radiation pneumonia of oesophageal carcinoma

Time : 12:20-12:50

Speaker
Biography:

Y L Gong has completed his PhD in Gastroenterology from 2nd Military Medical University of Shanghai. Currently, he is working as Professor in the Department of Oncology, Nanjing Hospital Affiliated to Nanjing Medical University, China. He has published more than 40 scientific papers in various national and international journals and a reviewer for reputed journals. Apart from medical oncology, his area of interest is in Chinese traditional medicine therapy of cancer.

Abstract:

The main objective is to observe the curative effect of Chinese herbal Decoction of Runfei combined with hormone and antibiotic in treating Radiation Pneumonia (RP) of esophageal carcinoma. A 56-year-old male underwent surgery for cancer of the upper esophagus (T3N2M0) in September 2014; following post-surgery adjuvant radiotherapy of the three-dimensional conformal radiotherapy which were administered. Two months later, severe pneumonia has been found by Chest X-ray and CT imaging, he received the treatment of hormone and antibiotic. In the mean-time, we administered Chinese herbal medicine, Fei Decoction, mixed with a variety of effective herbal components to help him to recover from the poor condition. After taking the Chinese herbs for 2 weeks, the diffuse patchy shadows and ground glass appearance on Chest X-ray dramatically decreased, with the result to the normal range, and the patient felt free from the complaint of pulmonary and cardiac discomfort. The quality of life has been greatly improved. Thus, we managed to have prolonged the PFS (Progression-Free-Survival) and TTP (Time-to-Progression) from the onset to date. In the course of this combined treatment, we showed that Chinese herbal medicine plays an important role in the therapy of esophageal carcinoma. Chinese herbs might be an additional choice with its better benefits and tolerability in the treatment of Radiation Pneumonia (RP) of esophageal carcinoma.

Min Yang

Capital Medical University, China

Title: Role of macrophage polarization in tumor metastasis

Time : 14:00-14:30

Speaker
Biography:

Min Yang is an Associate Professor of Beijing Anzhen Hospital, Capital Medical University. She received the PhD degree in Peking University in 2007. She is currently a Senior Visiting Scholar in the School of Medicine, University of Pittsburgh. She has published thirteen scientific papers in journals including Cell Death & Differentiation, Cell Death & Disease, Cell reports, ATVB and Molecular Cancer. Her projects have been continually supported by National or Beijing Science Foundation of China since 2010. She is a Reviewer of Cardiovascular Toxicology, Cardiovascular Therapeutics and Wound Repair and Regeneration. She is interested in identifying mechanisms of macrophage polarization in tumor microenvironment.

Abstract:

Tumor metastasis is affected by dynamic changes in the specific phenotypes of macrophage subpopulations; however, the mechanisms by which tumor cell modulates macrophage polarization remain unclear. Here, we investigated the molecular basis and signaling pathways between tumor cells and macrophage polarization and explored the underlying mechanism how to regulate cancer metastasis. We reported CARD9, a central adaptor protein of innate immune responses, which can contribute to tumor metastasis, associated with poor cancer prognosis via induction of metastasis-associated macrophages. Tumor cell secreted VEGF facilitates activation of the Syk signaling pathway in macrophages, leading to induction of the assembly of the CARD9–BCL10–MALT1 complex, following to activation of NF-kB pathway that mediated metastasis-associated macrophage polarization. Moreover, autophagic activity is a critical factor in tumor development that enhances cellular fitness and survival in the hostile tumor microenvironment. We demonstrated that Cat S-mediated autophagic flux is an important mechanism for inducing M2-type polarization of tumor-associated macrophages (TAMs), which leads to tumor development. Furthermore, efficient clearance of apoptotic cells (efferocytosis) can profoundly influence tumor-specific immunity. Our results suggest a novel mechanism by which ICAM-1 in the tumor microenvironment, via restraining efferocytosis of apoptotic tumor cells, can block M2 macrophage polarization through regulation of PI3K/AKT activation, which leads to prevention of tumor metastasis. Together with experimental and clinical findings, we propose a strategy to selectively target macrophage polarization in combination with the adaptor molecule of innate immune responses, autophagy, or efferocytosis, the novel approaches that could have significant therapeutic potential for cancer metastasis.

Ilana Nathan

Ben-Gurion University of the Negev, Israel

Title: Development of protective agents against necrotic cell death

Time : 14:30-15:00

Speaker
Biography:

Ilana Nathan has completed her PhD at Ben-Gurion University of the Negev, Beer-Sheva, Israel. Visiting Scientist at NCI, NIH, Bethesda, MD. Professor, Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva. Israel. Head of the Hematology Research Laboratory, Soroka University Medical Center, Beer Sheva. Israel. Served as a consultant of biotechnology companies. Delegate of Israel in the Biomedicine and Molecular Sciences domain in the European Organization for Cooperation in the field of Scientific and Technical Research. Published over 90 papers and has 12 patents.

Abstract:

Necrotic cell death leads to severe tissue damage in many clinical conditions. The molecular mechanisms underlying necrosis are poorly elucidated, and no drugs are available for its treatment or prevention. We identified key steps in the molecular pathway of necrosis. Necrosis induced in vitro by various reagents caused an early significant increase in intracellular proteolytic activity. We demonstrated selective inhibition of the necrotic process by specific protease inhibitors both in vitro and in vivo. The results indicate that activation of a protease pathway plays a regulatory key role in necrosis. We identified an additional approach for treatment of necrosis. Humanin (HN) is a 24-residue peptide known for its protective effect against Alzheimer’s disease related apoptosis. Recently, peripheral effects of humanin were observed. We have shown that HN derivatives have a protective effect against necrosis. Among the HN derivatives tested, HN17 was the most active against necrosis. HN peptides also induced an elevation of cellular ATP levels in cells challenged with necrosis. Most importantly, we have shown that the anti-necrotic effects of the HN derivatives were enhanced synergistically by combination with anti necrotic or pro-survival agents. Thus, the new strategies may serve as basis for the development of drug therapies for necrosis related diseases, e.g. traumatic brain injury, stroke, myocardial infarction and other conditions for which no efficient drug based treatment is currently available.

Satoshi Koikeda

Amano Enzyme Inc, Japan

Title: New concept of prebiotics: Prebiotic enzyme transglucosidase

Time : 16:20-16:50

Speaker
Biography:

Satoshi Koikeda has completed his PhD at 1990 from Kanazawa University in Japan and joined Amano Enzyme Inc. He is a general manager in frontier research department of Amano Enzyme Inc. He is interested in novel enzyme technology and enzyme application

Abstract:

The role of gut microbiota to influence human physiology, metabolism, nutrition and immune function has been highlighted. Gut microbiota is a community of microorganisms inhabiting in gastrointestinal tract and is thought to change in response to nutritional and physical condition. Nowadays, development of novel prebiotic and probiotic to keep gut microbiota at good balance is paid attention to prevent and treat chronic diseases. We are investigating prebiotic enzyme named transglucosidase (TGD). TGD is an enzyme catalyzing the synthesis of the prebiotics isomaltooligosaccharides from maltose. The randomized, double-blind, placebo-controlled study of TGD was conducted. Patients with type 2 diabetes (T2MD) were randomized to TGD orally 300 or 900 mg per day for 12 weeks. Blood and fecal samples were collected before and after 12 weeks. At 12 weeks, TGD 300 mg/day and TGD 900 mg/day significantly reduced HbA1c (0.18 and 0.21%) and insulin concentration (19.4 and 25.0 pmol/l), respectively, vs. placebo. In the placebo and TGD groups, the bacterial communities were generally similar before and after the treatment. However, after 12 weeks of TGD therapy, the Bacteroidetes-to-Firmicutes ratio in the TGD groups significantly increased and was significantly higher compared with that in the placebo group, indicating that TGD improved the growth of the fecal bacterial communities in the T2DM patients. Therefore, TGD treatment decreased blood glucose levels and prevented body weight gain in the T2DM patients by inducing the production of oligosaccharides in the alimentary tract and modulating gut microbiota composition.

Junko Nishimura

Hachinohe Institute of Technology, Japan

Title: Polysaccharide of lactic acid bacteria using as yogurt starter

Time : 16:50-17:20

Speaker
Biography:

Junko Nishimura graduated from Obihiro University of Agricultural and Veterinary Medicine. Upon entering the Graduate School of Agricultural Science, Tohoku University, she worked as a technical expert. She studied the function of dairy lactic acid bacteria in the Laboratory of Animal Products Chemistry, especially exopolysaccharide and bacteriocin of the Lactobacillus genus. She completed her PhD in the study of exopolysaccharide produced from Lactobacillus delbrueckii subsp. Bulgaricus in 2013 and is currently an Associate Professor at the Hachinohe Institute of Technology. Recently, she has also studied contributions to the environment by utilizing effective microorganisms.

Abstract:

Strains producing exocellular polysaccharide (EPS) exist in daily lactic acid bacteria. Lactobacillus delbrueckii subsp.bulgaricus and Streptococcus thermophilus, both of which contain EPS producing strains, are generally used for fermented milk manufacture. They are widely used to improve texture and prevent synthesis in fermented dairy products. The physiological functions of EPS, such as reducing the cholesterol concentration in the blood as well as decreasing infectivity against influenza, have also been demonstrated. We investigated the relationship between the chemical structure and physiological functions of EPS on L. bulgaricus OLL 1073R-1. In our previous studies, it was found that this EPS constituted two kinds of polysaccharides, i.e., neutral polysaccharide (NPS) and acidic polysaccharide (APS), both of which had the same carbohydrate structure, but different phosphorus contents. APS induced B-cell mitogenic activity on murine lymphocytes, though NPS did not show it. In addition, APS was able to augment the cyto-toxicity and the gene expression of several cytokines in macrophages. Based on these results, it is believed that the phosphorus group in EPS is important for modulating the immune response. Biosynthesis, phosphorylation and the linkage of the phosphate group of NPS and APS from L. bulgaricus OLL1073R-1 are still unknown. Especially, the phosphorylation of bacterial EPS is rare. EPS production of L. bulgaricus had been obtained by the horizontal transmission of EPS gene in S. thermophilus; however, there is no report of EPS containing phosphorus in S. thermophilus. We are planning to further examine these details in the future.

Azim Charoosaee

Islamic Azad University, Iran

Title: Relations between sports, diet and health

Time : 17:20-17:40

Speaker
Biography:

Azim Charoosaee is a faculty member in Physical Education at Islamic Azad University, Khouzestan Province, Iran. He taught for more than 20 years at University and Schools about physical education. His areas of interest are sports and physical education.

Abstract:

Physical education is the interdisciplinary study of physical activity, human movement and athletic performance. This course explores many aspects of anatomy and physiology, exercise physiology, sports injuries, rehabilitation, nutrition, psychology, biomechanics and socio cultural issues within sport and physical education. Diet can help combat depression and improve your mood. Depression саn be an offset or еvеn eliminated when the diet consists of nutritional and healthy foods. Indeed, сеrtаіn foods are not good for уоu physically but thеу аlѕо enhance уоur mental and emotional states аѕ well. There are many саuѕеѕ of depression and if уоu feel that depression іѕ а problem уоu ѕhоuld consult а licensed medical professional to get proper medical advice. This paper resulted in an annual research project will show that correct sport and true diet which will be very useful to a person health and they, altogether helps the man will be ready to do social activities better and even he/ she could be an athlete so, if he/she wants and follows it as a purpose.